Natalia
Gavrilova
Center on Aging, NORC at the University of Chicago
(Abstract
of presentation at the International Conference on Longevity, Sydney,
Australia, March 5-7, 2004)
In contrast to the remarkable
progress in the genetics of yeast and nematode aging, little is known
about genes that control human longevity. What is behind the records of
extreme human longevity: just lucky chance, favorable environment, or
'good' genes? How to resolve the apparent controversy between strong
familial clustering of human longevity, and poor resemblance in
lifespan among blood relatives?
Relevant Publications:
Gavrilov, L.A.,
Gavrilova, N.S. Early-life
factors modulating lifespan. In: Rattan, S.I.S. (Ed.).Modulating
Aging and Longevity. Kluwer Academic Publishers, Dordrecht, The
Netherlands, 2003, 27-50.
Gavrilova, N.S., Gavrilov, L.A. Evolution of Aging. In: David J. Ekerdt
(eds.) Encyclopedia of Aging, New York, Macmillan Reference USA, 2002,
vol. 2, 458-467.
Gavrilov, L.A., Gavrilova, N.S. Human
longevity and parental age at conception. In: J.-M.Robine et al.
(eds.) Sex and Longevity: Sexuality, Gender, Reproduction, Parenthood,
Berlin, Heidelberg: Springer-Verlag, 2000, 7-31.
Gavrilova N.S., Gavrilov L.A., Evdokushkina, G.N., Semyonova,
V.G. Early-life
predictors of human longevity: Analysis of the 19th Century birth
cohorts. Annales de Demographie Historique, 2003, 2: 177-198.
Gavrilova NS, Gavrilov LA, Semyonova VG, Evdokushkina GN. Does
Exceptional Human Longevity Come With High Cost of Infertility? Testing
the Evolutionary Theories of Aging. Biogerontology. 4(Suppl.1):
35-35, 19 Sep 2003
Gavrilov, L.A., Gavrilova, N.S. Evolutionary
theories of aging and longevity. TheScientificWorldJOURNAL,
2002, 2: 339-356. Available: http://www.thescientificworld.com/
Gavrilova, N.S., Gavrilov, L.A. When
does human longevity start?: Demarcation of the boundaries for human
longevity. Journal of Anti-Aging Medicine, 2001, 4(2): 115-124.
Gavrilov L.A., Gavrilova N.S. Epidemiology
of human longevity: The search for appropriate methodology. Journal
of Anti-Aging Medicine, 2001, 4(1): 13-30.
Gavrilov, L.A., Gavrilova, N.S. Biodemographic
study of familial determinants of human longevity. Population: An
English Selection, 2001, 13(1): 197-222.
Gavrilova, N.S.,
Gavrilov, L.A. Consanguinity
and human longevity: Findings from the International Centenarian Study.
Gerontologist, 2001, 41 (Sp. issue): 87-87.
Gavrilov, L.A.,
Gavrilova, N.S. Is
there a reproductive cost for human longevity? Journal of
Anti-Aging Medicine, 1999, 2(2): 121-123.
Gavrilova, N.S., Gavrilov, L.A., Evdokushkina G.N., Semyonova, V.G.,
Gavrilova, A.L., Evdokushkina, N.N., Kushnareva, Yu.E., Kroutko, V.N.,
Andreyev, A.Yu. Evolution,
mutations and human longevity. Human Biology, 1998, 70(4): 799-804.
Gavrilov, L.A., Gavrilova, N.S. Parental
age at conception and offspring longevity. Reviews in Clinical
Gerontology, 1997, 7: 5-12.
Gavrilov L.A., Gavrilova, N.S., Kroutko, V.N., Evdokushkina, G.N.,
Semyonova, V.G., Gavrilova, A.L., Lapshin, E.V., Evdokushkina N.N.,
Kushnareva, Yu.E. Mutation
load and human longevity. Mutation Research, 1997, 377(1): 61-62.
Gavrilov, L.A., Gavrilova, N.S. When Fatherhood
Should Stop? Letter. Science, 1997, 277(5322): 17-18.